[ExI] PaleoCRON?

Jones Murphy morphy at alumni.caltech.edu
Tue Apr 26 19:35:53 UTC 2011

It's already clear that CR will produce a boost of decades for those
prone to diabetes and cardiovascular problems, so Aubrey and Michael
are already just flat out wrong on those types. The remainder are
those prone to cancer and other causes of death, maybe 50% of humans.
Again on cancer, CR is looking good but the numbers are not yet in in
the way that they are for diabetes and cardiovascular diseases of
various kinds. It's not looking so great for the remainder, so
something like 25% may only get the modest boost. So I'd say a boost
of decades is very likely overall. But the data is  not in on humans
specifically yet and will not be for a long, long time. None of us
will be around to see Aubrey and Michael definitively proven right or
wrong, that's for sure. I come from diabetes- and cardiovascular
disease-prone stock, so it's an easy choice for me.

2011/4/26 Max More <max at maxmore.com>:
> We really don't yet know how much of a boost CR will give to the human life
> span. Note that both Aubrey de Grey and Michael Rose expect that CR produces
> results that are closer to absolute than relative to the species.
> This means, if they are correct, that humans will enjoy a quite modest
> extension, nothing like decades.
> I agree with Stefano about the downsides to moderate-to-severe CR. On the
> other hand, I see all kinds of good reasons to practice mild-to-modest CR in
> the form of intermittent fasting and portion control as part of a NeoPaleo
> approach. Doing fasting while on a NeoPaleo diet is easier, because blood
> sugar levels are more stable and hunger less acute.
> --- Max
> On Tue, Apr 26, 2011 at 12:04 PM, Jones Murphy <morphy at alumni.caltech.edu>
> wrote:
>> Agreed, Stefano, that Paleo does cut calories relative to typical
>> modern diets. Most people do not have anywhere near the genetic
>> potential of an Olympic athlete, so I'm not clear why that's the
>> standard you hold CR in particular to...? If you have miserable
>> athletic potential to start with, why would you care about sacrificing
>> athletic performance to spend more than marginally more years in
>> comfort down the road? CR yields about 1% lifespan per 1% reduction in
>> calorie intake, up to well over 60% in the studies of animals. That
>> ain't marginal my friend, esp considering the quality of life, late in
>> life.
>> --
> Max More
> Strategic Philosopher
> Co-founder, Extropy Institute
> CEO, Alcor Life Extension Foundation
> 7895 E. Acoma Dr # 110
> Scottsdale, AZ 85260
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