[ExI] PaleoCRON?

Jones Murphy morphy at alumni.caltech.edu
Wed Apr 27 17:36:26 UTC 2011

On Wed, Apr 27, 2011 at 6:49 PM, Stefano Vaj <stefano.vaj at gmail.com> wrote:

> - I am much less sure, but try to keep an open mind, with regard to
> possible longevity benefits from a CR cutting on the food intake which
> would otherwise assumed by a healthy individual whose metabolism and
> nutritional inclinations are not altered by tolerance/addiction (or
> stress) mechanisms.
> - Even if such benefits do exist, I would be very reluctant to pursue
> them if I had to pay (or beyond the level where I would have to pay) a
> price not just in terms of quality of life, but in my, actual or
> potential, physical or intellectual or sensorial present performances
> in any conceivable field.

There is plenty of evidence of the physical price to be paid for CR,
beginning with reduced size for infancy-onset CR. For those who do not
aspire to be athletes, that price can be worth paying so as to delay
physical and mental deterioration by decades, let alone death..
Evidence for any mental price is not so clear yet, with CR animals
always performing at or above normal early on, and very much above
normal late in life. It appears the brain is very well defended.

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