[ExI] good bexarotene article

The Avantguardian avantguardian2020 at yahoo.com
Sun Feb 12 06:09:07 UTC 2012


----- Original Message -----
> From: spike <spike66 at att.net>
> To: 'ExI chat list' <extropy-chat at lists.extropy.org>
> Cc: 
> Sent: Saturday, February 11, 2012 10:41 AM
> Subject: Re: [ExI] good bexarotene article
> 
>> ... On Behalf Of Jeff Davis
> ...
> 
>> ...Best outcome:  an effective off-label (ie non-FDA "owned") 
> Alzheimer's
> therapy that becomes the champion example for patients' rights.  Best, Jeff
> Davis
> 
> 
> Ja well said.  Yesterday we made some calls, learned that it is generally OK
> for a GP to prescribe off-label at the doctor's discretion.  We have a
> message in to our family member's doctor asking if she is willing to
> prescribe bexarotene off-label, or do we need to go find a doctor who will.
> 
> The next thing we need is to calculate or estimate the dosage.  For a first
> shot, I am trying to find out what dose they gave the mice, then scale it up
> linearly.  Would you estimate a mouse is about 50 to 60 grams?  So whatever
> the mice received, scale it up by a factor of about 1000?  
> 
> The medications which contain bexarotene supply the information of the
> concentration of the active ingredient, so it will be an easy calculation.  
> 
> Open to suggestion here.  The topic is temporarily open season, so your
> suggestion is free and welcome.

Does anybody have an institutional Science subscription that could send me a copy of this article?

http://www.sciencemag.org/content/early/2012/02/08/science.1217697

The dosing information and administration route are probably in there.

Stuart LaForge


"When the going gets weird, the weird turn pro." - Hunter S. Thompson



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