[ExI] good bexarotene article

[The Avantguardian]

----- Original Message -----
> From: Mike Dougherty <msd001 at gmail.com>
> To: ExI chat list <extropy-chat at lists.extropy.org>
> Cc: 
> Sent: Saturday, February 11, 2012 4:47 PM
> Subject: Re: [ExI] good bexarotene article
> 
> On Sat, Feb 11, 2012 at 3:17 PM, BillK <pharos at gmail.com> wrote:
>> Targretin Capsule Initial Dose Calculation According to Body Surface
>> Area Initial Dose Level (300 mg/m2/day)
>> Body Surface Area (m2)  Total Daily Dose (mg/day)
>> 0.88 - 1.12                     300
>> 1.13 - 1.37                     375
>> 1.38 - 1.62                     450
>> 1.63 - 1.87                     525
>> 1.88 - 2.12                     600
>> 2.13 - 2.37                     675
>> 2.38 - 2.62                     750
> 
> If you were asking how many applications of sunscreen per bottle, I
> would understand measurement by surface area.  In this case, how does
> measurement of dosage by surface area of the body indicate a correct
> application of neural-affecting drugs?

Because muscle is denser than fat. A lean but muscular man can weigh as much or more than an obese woman but have less flesh. Drugs have to diffuse throughout the whole body to get to where they need to operate. As such, if you dose by weight, the man would overdose but the woman would be fine. Doctors dose by surface area because that is more indicative of what the patient's true cellular volume is than simple weight.

Stuart LaForge