[ExI] good bexarotene article
spike66 at att.net
Wed Feb 15 23:03:42 UTC 2012
>... On Behalf Of Amara D. Angelica
Subject: Re: [ExI] good bexarotene article
>>...Spike said: "Perhaps I should have thought of it: there were
researchers who were giving a skin cancer medication to Alzheimer's mice.
Why were they doing that?"
Amara Angelica found the comment:
>..."We reasoned that an RXR [retinoid X receptors]agonist would enhance
normal Aβ [β-amyloid] clearance mechanisms by activating PPAR:RXR
[peroxisome proliferator activated receptor] and LXR:RXR [liver X
receptors], inducing apoE expression, facilitating Aβ clearance and
promoting microglial phagocytosis...
I do like those words, "...we reasoned that..." and "...promoting microglial
phagocytosis..." This might be BIG!
>... Bexarotene (TargretinTM) is a highly selective, blood brain
Oooooh baby now THERE'S some sexy words: Bexarotene is a highly selective
blood brain barrier permeant. Keep telling me that, ooooh.
>...FDA-approved, RXR agonist (11) with a favorable safety profile (12)."
Cramer's video: http://bit.ly/zj8xrw Amara
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