[ExI] Jaw-dropping CWRU Alzheimer's breakthrough?

Rafal Smigrodzki rafal.smigrodzki at gmail.com
Fri Feb 17 22:59:06 UTC 2012


Any work done in amyloid mice is likely to be useless - the models are
wrong on many levels, from the fact that they are using mutated
proteins (which are almost always absent in senile dementia), to using
combinations of mutated proteins (which almost never happens in senile
dementia), to the lack of pathology in response to the mutated
proteins (which indicates the mouse's brain reacts differently on the
biochemical level than human brain). These mice have essentially no
construct validity for senile dementia, misleadingly called
"Alzheimer's disease", and only poor to middling construct validity
for the true Alzheimer's dementia which is a very uncommon familial
disease affecting young and middle age adults.

Save your money, until you see results in aged dogs or monkeys (not
mutated). If somebody publishes a non-human primate study showing a
good cognitive boost in 25 year old rhesus monkeys, I would be very
impressed.

Rafal


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