[ExI] Cryonics punched cards and the brain

colin hales col.hales at gmail.com
Sun Jan 24 23:44:32 UTC 2016

A really informative YouTube by sejnowski on the 3d structure of neuropil that also leads to the extracellular matrix. 40-110nm thick. Sheet/tunnel matrix. 


-----Original Message-----
From: "Anders Sandberg" <anders at aleph.se>
Sent: ‎24/‎01/‎2016 11:51 PM
To: "extropy-chat at lists.extropy.org" <extropy-chat at lists.extropy.org>
Subject: Re: [ExI] Cryonics punched cards and the brain

Neat. Generally LTP is seen as the first of a longer cascade of fixation of memories. Most research has been about cellular skeleton changes, but perineuronal nets might also work. 

It might actually be a good experiment for cryonics to see what the process does to these nets. (I think John mixed up the perioneuronal net (protein networks) with perineuronal space in the sleep reference. )

Incidentally, the Sejnowski lab had a nice result on the distribution of synaptic strengths:
Bartol, T. M. Jr. Bromer, C. Kinney, J. P. Chirillo, M. A. Bourne, J. N. Harris, K. M. Sejnowski, T. J. Nanoconnectomic upper bound on the variability of synaptic plasticity, eLife, 4:e10778, 2015 

They show that each synapse stores at most about 4.7 bits. While their press material claims this is "an order of magnitude more" than previous estimates, the actual estimate most people have been doing is about one bit, so the difference isn't dramatic. But doing nanoconnectomics is an awesome method.

Dr Anders Sandberg
Future of Humanity Institute
Oxford Martin School
Oxford University
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