[ExI] prostate cancer

[Dylan Distasio]

Unfortunately, I'm going to be somewhat unhelpful as I'm not entirely
sure.  I already take metformin myself (along with rapamycin) for the
potential healthspan improvements (I'm not prediabetic/diabetic).  I've
actually toyed with the idea of adding berberine also but am focused on
other items in the overall cocktail right now and the costs overall start
to add up.

I don't think the combination would have any negative effect on pushing
your blood sugar too low due to their mechanism of action (metformin
amongst other things tamps down the creation of glucose by the liver
(gluconeogenesis) but does not otherwise actually remove glucose from the
blood, which makes it a very safe drug in that regard).

Just in case, I would keep an eye on your fasting blood glucose though, and
I guess just monitor how you're feeling overall.  Sorry that I don't have
something more quantitative to suggest.

I would be very interested in hearing about your results though, and good
luck with the continued fight against the prostate cancer.

On Tue, Nov 19, 2019 at 11:06 AM William Flynn Wallace via extropy-chat <
extropy-chat at lists.extropy.org> wrote:

> Thanks!  What side effects should I be looking for ?   bill w
>
> On Tue, Nov 19, 2019 at 9:51 AM Dylan Distasio via extropy-chat <
> extropy-chat at lists.extropy.org> wrote:
>
>> I would suggest being careful about noticing any side effects from
>> combining it with metformin as they both target AMPK.  Not arguing against
>> combining them, but just be aware that they hit many of the same molecular
>> pathways.
>>
>> On Tue, Nov 19, 2019 at 10:42 AM William Flynn Wallace via extropy-chat <
>> extropy-chat at lists.extropy.org> wrote:
>>
>>> I have had it for over 20 years.  A Gleason score of 4 means low
>>> aggressiveness.  However, my PSA is going up.  This article suggests that
>>> berberine can not only hinder prostate cancer but hold PSA steady.  At $20
>>> for three months I am adding it to my pile.  Article also says that it
>>> controls blood sugar as well as metformin, which I also take.  Hah!  I
>>> might have to eat cake to keep my blood sugar up!  Here is the link.  I
>>> suggest you add People's Pharmacy to your email list and get their weekly
>>> bulletin.  Highly educated people.  They don't sell any drugs or
>>> supplements.
>>>
>>> bill w
>>>
>>>
>>> https://www.peoplespharmacy.com/articles/does-berberine-protect-against-prostate-cancer/?utm_source=The+People%27s+Pharmacy+Newsletter&utm_campaign=b59450b87d-MC_D_2019-11-19%26subscriber%3D1&utm_medium=email&utm_term=0_7300006d3c-b59450b87d-214968749&goal=0_7300006d3c-b59450b87d-214968749&mc_cid=b59450b87d&mc_eid=b9c6f5005a
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