[ExI] prostate cancer

Dylan Distasio interzone at gmail.com
Tue Nov 19 16:17:58 UTC 2019


I would add you could monitor your liver enzyme levels just to ensure
you're not taxing the system in any way there.   Blood tests for that
specifically should be pretty cheap.

Also meant to add that if you're not aware of it already, metformin can
block your ability to ingest B12 so over time you can run into severe
issues like neuropathy from it if you're not getting enough B12 to overcome
this side effect.  I would definitely supplement with a B complex or B12 on
a regular basis and get your B12 levels checked biannually.  The neuropathy
will not be reversible so it is important that you don't run a B12
deficiency for an extended period of time.

On Tue, Nov 19, 2019 at 11:14 AM Dylan Distasio <interzone at gmail.com> wrote:

> Unfortunately, I'm going to be somewhat unhelpful as I'm not entirely
> sure.  I already take metformin myself (along with rapamycin) for the
> potential healthspan improvements (I'm not prediabetic/diabetic).  I've
> actually toyed with the idea of adding berberine also but am focused on
> other items in the overall cocktail right now and the costs overall start
> to add up.
>
> I don't think the combination would have any negative effect on pushing
> your blood sugar too low due to their mechanism of action (metformin
> amongst other things tamps down the creation of glucose by the liver
> (gluconeogenesis) but does not otherwise actually remove glucose from the
> blood, which makes it a very safe drug in that regard).
>
> Just in case, I would keep an eye on your fasting blood glucose though,
> and I guess just monitor how you're feeling overall.  Sorry that I don't
> have something more quantitative to suggest.
>
> I would be very interested in hearing about your results though, and good
> luck with the continued fight against the prostate cancer.
>
> On Tue, Nov 19, 2019 at 11:06 AM William Flynn Wallace via extropy-chat <
> extropy-chat at lists.extropy.org> wrote:
>
>> Thanks!  What side effects should I be looking for ?   bill w
>>
>> On Tue, Nov 19, 2019 at 9:51 AM Dylan Distasio via extropy-chat <
>> extropy-chat at lists.extropy.org> wrote:
>>
>>> I would suggest being careful about noticing any side effects from
>>> combining it with metformin as they both target AMPK.  Not arguing against
>>> combining them, but just be aware that they hit many of the same molecular
>>> pathways.
>>>
>>> On Tue, Nov 19, 2019 at 10:42 AM William Flynn Wallace via extropy-chat <
>>> extropy-chat at lists.extropy.org> wrote:
>>>
>>>> I have had it for over 20 years.  A Gleason score of 4 means low
>>>> aggressiveness.  However, my PSA is going up.  This article suggests that
>>>> berberine can not only hinder prostate cancer but hold PSA steady.  At $20
>>>> for three months I am adding it to my pile.  Article also says that it
>>>> controls blood sugar as well as metformin, which I also take.  Hah!  I
>>>> might have to eat cake to keep my blood sugar up!  Here is the link.  I
>>>> suggest you add People's Pharmacy to your email list and get their weekly
>>>> bulletin.  Highly educated people.  They don't sell any drugs or
>>>> supplements.
>>>>
>>>> bill w
>>>>
>>>>
>>>> https://www.peoplespharmacy.com/articles/does-berberine-protect-against-prostate-cancer/?utm_source=The+People%27s+Pharmacy+Newsletter&utm_campaign=b59450b87d-MC_D_2019-11-19%26subscriber%3D1&utm_medium=email&utm_term=0_7300006d3c-b59450b87d-214968749&goal=0_7300006d3c-b59450b87d-214968749&mc_cid=b59450b87d&mc_eid=b9c6f5005a
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