[ExI] prostate cancer

Tue Nov 19 22:05:30 UTC 2019

How are you getting rapamycin?  Thanks!  bill w

On Tue, Nov 19, 2019 at 10:39 AM Dylan Distasio via extropy-chat <
extropy-chat at lists.extropy.org> wrote:

> I would add you could monitor your liver enzyme levels just to ensure
> you're not taxing the system in any way there.   Blood tests for that
> specifically should be pretty cheap.
>
> Also meant to add that if you're not aware of it already, metformin can
> block your ability to ingest B12 so over time you can run into severe
> issues like neuropathy from it if you're not getting enough B12 to overcome
> this side effect.  I would definitely supplement with a B complex or B12 on
> a regular basis and get your B12 levels checked biannually.  The neuropathy
> will not be reversible so it is important that you don't run a B12
> deficiency for an extended period of time.
>
> On Tue, Nov 19, 2019 at 11:14 AM Dylan Distasio <interzone at gmail.com>
> wrote:
>
>> Unfortunately, I'm going to be somewhat unhelpful as I'm not entirely
>> sure.  I already take metformin myself (along with rapamycin) for the
>> potential healthspan improvements (I'm not prediabetic/diabetic).  I've
>> actually toyed with the idea of adding berberine also but am focused on
>> other items in the overall cocktail right now and the costs overall start
>> to add up.
>>
>> I don't think the combination would have any negative effect on pushing
>> your blood sugar too low due to their mechanism of action (metformin
>> amongst other things tamps down the creation of glucose by the liver
>> (gluconeogenesis) but does not otherwise actually remove glucose from the
>> blood, which makes it a very safe drug in that regard).
>>
>> Just in case, I would keep an eye on your fasting blood glucose though,
>> and I guess just monitor how you're feeling overall.  Sorry that I don't
>> have something more quantitative to suggest.
>>
>> I would be very interested in hearing about your results though, and good
>> luck with the continued fight against the prostate cancer.
>>
>> On Tue, Nov 19, 2019 at 11:06 AM William Flynn Wallace via extropy-chat <
>> extropy-chat at lists.extropy.org> wrote:
>>
>>> Thanks!  What side effects should I be looking for ?   bill w
>>>
>>> On Tue, Nov 19, 2019 at 9:51 AM Dylan Distasio via extropy-chat <
>>> extropy-chat at lists.extropy.org> wrote:
>>>
>>>> I would suggest being careful about noticing any side effects from
>>>> combining it with metformin as they both target AMPK.  Not arguing against
>>>> combining them, but just be aware that they hit many of the same molecular
>>>> pathways.
>>>>
>>>> On Tue, Nov 19, 2019 at 10:42 AM William Flynn Wallace via extropy-chat
>>>> <extropy-chat at lists.extropy.org> wrote:
>>>>
>>>>> I have had it for over 20 years.  A Gleason score of 4 means low
>>>>> aggressiveness.  However, my PSA is going up.  This article suggests that
>>>>> berberine can not only hinder prostate cancer but hold PSA steady.  At $20
>>>>> for three months I am adding it to my pile.  Article also says that it
>>>>> controls blood sugar as well as metformin, which I also take.  Hah!  I
>>>>> might have to eat cake to keep my blood sugar up!  Here is the link.  I
>>>>> suggest you add People's Pharmacy to your email list and get their weekly
>>>>> bulletin.  Highly educated people.  They don't sell any drugs or
>>>>> supplements.
>>>>>
>>>>> bill w
>>>>>
>>>>>
>>>>> https://www.peoplespharmacy.com/articles/does-berberine-protect-against-prostate-cancer/?utm_source=The+People%27s+Pharmacy+Newsletter&utm_campaign=b59450b87d-MC_D_2019-11-19%26subscriber%3D1&utm_medium=email&utm_term=0_7300006d3c-b59450b87d-214968749&goal=0_7300006d3c-b59450b87d-214968749&mc_cid=b59450b87d&mc_eid=b9c6f5005a
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