[ExI] First hint that body’s ‘biological age’ can be reversed

[Darin Sunley]

It sounds awesome if it works, but my first response upon reading it was
"feeding a drug cocktail to 9 guys, with no control group? I'm not sure
what you call that, but 'science' doesn't seem like quite the right word."

On Fri, Sep 6, 2019, 2:10 PM John Clark via extropy-chat <
extropy-chat at lists.extropy.org> wrote:

> The study was conducted by cryobiologist Dr. Gregory Fahy and involved
> Human Growth Hormone and two common diabetes drugs, dehydroepiandrosterone
> (DHEA) and metformin. The results are interesting because it didn't just
> slow down the biological clock it reversed it, but it may not be rock solid
> because the clinical study was small ( just 9 white men between 51 and 65)
> and it did not contain a control. The discovery was an accident, the drug
> trial was set up to see if growth hormone could be safely used to restore
> the thymus gland and anti-diabetic drugs were only included because
> growth hormone can cause diabetes. After the trial was over they found that
> in 7 of the 9 men the thymus was restored, and then as an afterthought
> Fahy checked on their epigenetic clock and got a surprise.
>
> It seems to me the next step should be to try this drug cocktail in mice
> and see if they live longer.
>
> Drugs seemed to rejuvenate the body’s ‘epigenetic clock
> <https://www.nature.com/articles/d41586-019-02638-w?utm_source=Nature+Briefing&utm_campaign=eae3387943-briefing-dy-20190906&utm_medium=email&utm_term=0_c9dfd39373-eae3387943-44221073>
>
> John K Clark
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>
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