[ExI] First hint that body’s ‘biological age’ can be reversed

[William Flynn Wallace]

Here is a long article on rapamycin by an M.D.

https://rapamycintherapy.com/

On Sun, Sep 8, 2019 at 10:22 AM Dave Sill via extropy-chat <
extropy-chat at lists.extropy.org> wrote:

> This is long but has lots of details missing from the popular press
> coverage. I'm just including the intro because the article has graphics and
> links and because of copyright law.
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> https://joshmitteldorf.scienceblog.com/2019/09/07/1st-age-reversal-results-is-it-hgh-or-something-else/
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> *Yesterday, the TRIIM study was described in science news headlines around
> the world, though, through a glitch, the original research paper is not yet
> on the Aging Cell web site. (You saw it first here.) I refer you to the
> writeup in Nature’s News section for a full summary of the paper, and in
> this column I will add my personal framing, and what I know about the study
> from private connection to its authors and one of the subjects. The big
> news is setback of the epigenetic clock, by several methylation measures.
> Instead of getting a year older during the trial, nine subjects got a year
> younger, on average, based on the version of the Horvath methylation clock
> that best predicts lifespan. The study had been originally designed to
> regrow the thymus. (Loss of thymus function has been linked to the collapse
> of the immune system that occurs typically before age 70.)  Imaging showed
> that the functional part of the thymus expanded over the course of the
> trial, and blood tests confirmed improved immune function. The treatment
> included human growth hormone (HGH)MetforminVitamin DZincDHEAIt is my
> belief that the age of our bodies is controlled by several biological
> clocks. (Greg Fahy, who conceived and conducted the TRIIM study, shares
> this perspective.) Candidates for clocks include Thymic
> involutionMethylation profileTimekeeper in the hypothalamusTelomere
> lengthPerhaps some changing homeostatic state of signal molecules and
> transcription factors circulating in the bloodThis story is about #1 and
> #2.  To be explicit, I’m saying that the body doesn’t wear out with age,
> but rather aging is a continuation of the timed growth and development
> program into a phase of late-life self-destruction. Just as growth and
> development are under epigenetic control. *
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