[ExI] What are everyone's life extension strategies?

[Dylan Distasio]

The CV-19 is an additional wrench in the works, but when rapamycin is
pulsed at low doses, the immunosuppressive effects are negated (there's
actually some evidence it may even boost immunity).   At daily, high doses,
it's used as part of an immunosuppressive regime for organ transplants, but
at once weekly, low doses, the bulk of these effects appear to be mitigated.

There are two complexes related to rapaymycin's method of action mTORC1 and
mTORC2 (mTOR actually stands for Target of Rapamycin).   mTORC1 is related
to nutrient sensing and is the one life extension enthusiasts are
interested in.  mTORC2 is related to growth factor signalling.   The theory
here is that mTORC2 activation is responsible for the nasty side effects of
rapamycin at daily, high doses, and that it is possible to activate mTORC1
with weekly low doses, and minimize mTORC2 activation.

This is a bit on the both of them, but if you want to read up on this stuff
in general, mTOR is the pathway you want to look at:

https://pubmed.ncbi.nlm.nih.gov/31010692/#:~:text=mTOR%20forms%20two%20multiprotein%20complexes,PI3K%20and%20growth%20factor%20signaling.


I've been taking it for over a year, and all of my high level blood work
still looks normal.   There are always potential risks with any
pharmaceutical intervention, and I would recommend you do your own research
and speak to a doctor.  You may have difficulty getting most doctors to
prescribe it.  I went to someone who retired years ago from his regular
practice but is such a big believer in it based on the research and his
personal results that he has built a new practice around it in his 70s.

On Tue, Aug 11, 2020 at 10:58 AM BillK via extropy-chat <
extropy-chat at lists.extropy.org> wrote:

> On Tue, 11 Aug 2020 at 15:43, Dylan Distasio via extropy-chat
> <extropy-chat at lists.extropy.org> wrote:
> >
> >
> > I am NOT a doctor, so you do need to do your own due diligence, but as
> I've mentioned on list before, one of the pharmaceutical interventions I
> take for potential anti-aging benefits is pulsed rapamycin (meaning I take
> it once a week in an attempt to avoid undesirable side effects).  It has a
> fairly long half life, so the argument can be made that pulsing it makes
> sense for a few reasons.
> >
> > Anyways, I'm bringing it up again because there is enough animal
> evidence that it reverses an enlarged heart (hypertrophy) for it to be
> worth considering for you in addition to the other potential benefits.  In
> fact, the doctor who prescribed it for me is an elderly gentleman who
> decided to take it for an enlarged heart after he noticed trouble walking
> up a hill he had not had problems with in the past.   Anecdotally, he has
> had very good success with it.  Here are a few animal studies on it:
> >
> > Abstract
> > Rapamycin, also known as sirolimus, is an antifungal agent and
> immunosuppressant drug used to prevent organ rejection in transplantation.
> <snip>
>
>
> "Immunosuppressant" ??  Is it safe to weaken the immune system when
> surrounded by Covid-19? Especially for an older person?
>
>
> BillK
>
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