[ExI] Essential Upload Data

John Clark johnkclark at gmail.com
Mon May 11 14:17:57 UTC 2020

On Mon, May 11, 2020 at 4:08 AM Ben Zaiboc via extropy-chat <
extropy-chat at lists.extropy.org> wrote:

*> If aldehyde stabilisation cross-links proteins, why is cryopreservation
> required?*

If you're only interested in very short term storage freezing wouldn't be
required, but even though the microscopic parts of the brain have been
physically locked in place, at room temperatures chemical reactions can
still occur. To a rough approximation the speed of a chemical reaction
doubles with every 10 degree Centigrade increase in temperature. Even dry
ice at -78 C  would only be good for storage of a few months, but with
liquid nitrogen at -196C you'd be OK for many centuries. Even -135C would
be cold enough and some prefer that temperature because it avoids cracking,
but that's a minor problem that I don't think is worth the greater expense,
and the added complexity dramatically decreases my confidence low
temperatures can reliably be maintained for a very long time. Complex
things need more maintenance than simple things and I can't predict what
the quality or quantity of Alcor's future maintenance abilities will be.

The advantage of ASC is that as the brain freezes the microscopic parts of
the brain are not pushed out of place, that's why I think it would be
better than the vitrification process that Alcor currently uses. And if it
turns out that push is chaotic then ASC is not only better it's the only
method that has a chance of working. Actually I don't think it's chaotic, I
think the flow is probably Laminar, but why take the chance, and why make
things for the people (or whatever) that want to revive us more difficult
than they need to be.

John K Clark
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