[ExI] Surprise! Our Bodies Have Been Hiding a Trojan Horse for Gene Therapy

[William Flynn Wallace]

Yes, being in the first wave of gene therapy patients will probably be bad,
humans tend to fuck things up  will

How many scientific discoveries occurred the very first time something was
tried?  I'd say probably none.  Every success rests atop a mountain of
failures.   bill w

On Wed, Aug 25, 2021 at 2:39 AM Will Steinberg via extropy-chat <
extropy-chat at lists.extropy.org> wrote:

> Yes, being in the first wave of gene therapy patients will probably be
> bad, humans tend to fuck things up
>
> On Wed, Aug 25, 2021, 12:37 AM Darin Sunley via extropy-chat <
> extropy-chat at lists.extropy.org> wrote:
>
>> That's really cool, but discovering the mechanism is one thing. Building
>> a working therapy to use it is another thing entirely. And then convincing
>> the population at large that it's safe and reliable - that'll be the
>> hardest trick of all. Popular trust in the institution of public health
>> policy is at an all-time low, and they've no one to blame but themselves.
>>
>> The politicization of the discourse around the known side-effects of the
>> mRNA vaccines being currently marketed has probably set genetic therapy as
>> a field back 30 years or more.
>>
>> On Tue, Aug 24, 2021 at 6:42 PM John Grigg via extropy-chat <
>> extropy-chat at lists.extropy.org> wrote:
>>
>>> "Enter SEND. The new delivery platform, described in
>>> <https://science.sciencemag.org/content/373/6557/882> *Science*,
>>> dazzles with its sheer ingenuity. Rather than relying on foreign carriers,
>>> SEND (*s*elective *e*ndogenous e*n*capsidation for cellular *d*elivery)
>>> commandeers human proteins to make delivery vehicles that shuttle in new
>>> genetic elements. In a series of tests, the team embedded RNA cargo and
>>> CRISPR components inside cultured cells in a dish. The cells, acting as
>>> packing factories, used human proteins to encapsulate the genetic material,
>>> forming tiny balloon-like vessels that can be collected as a treatment.
>>>
>>> Even weirder, the source of these proteins relies on viral genes
>>> domesticated eons ago by our own genome through evolution. Because the
>>> proteins are essentially human, they’re unlikely to trigger our immune
>>> system.
>>>
>>> Although the authors only tried one packaging system, far more are
>>> hidden in our genomes. “That’s what’s so exciting,” said study author Dr.
>>> Michael Segel, adding that the system they used isn’t unique; “There are
>>> probably other RNA transfer systems in the human body that can also be
>>> harnessed for therapeutic purposes.”
>>>
>>> https://singularityhub.com/2021/08/24/surprise-our-bodies-have-been-hiding-a-trojan-horse-for-gene-therapy/
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