[ExI] way to go brits!

Sat Dec 31 02:15:54 UTC 2022

Spike-

I am not anti-vax, but I am anti mRNA technology.   There are a lot more
problems with these "vaccines" beyond the fact the risk analysis does not
work out for young people.   Firstly, the nanoparticles carrying mRNA to
produce a cytotoxic protein (the spike) do not stay localized to the
injection site as promised, and rapidly spread throughout most tissues in
the body (to varying degrees based on organ).

The mRNA used for the spike protein was also modified to be stable longer,
and is turning out to persist way longer than the typical 2-4 days that
natural mRNA lasts in the body.   There is evidence that it persists at
least 90 days, but may persist even longer (the study I saw stopped at 90
days).

This means you have a bunch of cells producing spike protein in various
tissues that can lead to things like myocarditis, but also autoimmune
disorders, and other assorted maladies.

More recently, there is some very troubling news coming out of Science mag,
that repeated boosters (and even the initial series).   After initial
vaccination, the expected IgG1/IgG3 immunoglobulins are produced which are
typical of an immune reaction against an invader.    However, there is
quickly a large shift (again exacerbated by boosters) from IgG1/IgG3 to
IgG4 which is generally involved in building tolerance to allergens, and
should not be happening with a vaccine.

This behavior does not occur with Covid vaccines built on other tech like
the JNJ one.   The exact impact is unknown but there is a signal here that
mRNA vaccines may ultimately be telling the immune system to build a
tolerance to spike protein.   If so, this is a huge problem, and would also
explain the papers that have actually shown *negative *efficacy against
Covid with repeated boosters.

Here is the abstract from the Science paper:
Class switch towards non-inflammatory, spike-specific IgG4 antibodies after
repeated SARS-CoV-2 mRNA vaccination
SCIENCE IMMUNOLOGY
22 Dec 2022
First Release
DOI: 10.1126/sciimmunol.ade2798

*Abstract*
RNA vaccines are efficient preventive measures to combat the SARS-CoV-2
pandemic. High levels of neutralizing SARS-CoV-2-antibodies are an
important component of vaccine-induced immunity. Shortly after the initial
two mRNA vaccine doses, the IgG response mainly consists of the
pro-inflammatory subclasses IgG1 and IgG3. Here, we report that several
months after the second vaccination, SARS-CoV-2-specific antibodies were
increasingly composed of non-inflammatory IgG4, which were further boosted
by a third mRNA vaccination and/or SARS-CoV-2 variant breakthrough
infections. IgG4 antibodies among all spike-specific IgG antibodies rose on
average from 0.04% shortly after the second vaccination to 19.27% late
after the third vaccination. This induction of IgG4 antibodies was not
observed after homologous or heterologous SARS-CoV-2 vaccination with
adenoviral vectors. Single-cell sequencing and flow cytometry revealed
substantial frequencies of IgG4-switched B cells within the spike-binding
memory B-cell population (median 14.4%; interquartile range (IQR)
6.7–18.1%) compared to the overall memory B-cell repertoire (median 1.3%;
IQR 0.9–2.2%) after three immunizations. *Importantly, this class switch
was associated with a reduced capacity of the spike-specific antibodies to
mediate antibody-dependent cellular phagocytosis and complement deposition.
Since Fc-mediated effector functions are critical for antiviral immunity,
these findings may have consequences for the choice and timing of
vaccination regimens using mRNA vaccines, including future booster
immunizations against SARS-CoV-2.*

https://www.science.org/doi/10.1126/sciimmunol.ade2798

Personally, based on reviewing a lot of troubling signals in aggregate, I
would stay far away from mRNA technology.    There are too many unknowns
that were not adequately tested for.

I have a teenage daughter and have stuck to my guns on her not getting
vaccinated (she's already had Covid along with everyone else in the house
regardless of vaccination status in the adults).   This cost us an
opportunity to send her to a well regarded private high school, but her
health is more important.

On Fri, Dec 30, 2022 at 8:59 PM spike jones via extropy-chat <
extropy-chat at lists.extropy.org> wrote:

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> BillK, Max, we are honored by your presence and we are proud of your home
> country.  The British have done extensive enough statistical analysis to
> publish a paper which would not be allowed to circulate in the USA until
> Musk bought Twitter:
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> https://jme.bmj.com/content/early/2022/12/05/jme-2022-108449
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> …To prevent one COVID-19 hospitalisation over a 6-month period, we
> estimate that 31 207–42 836 young adults aged 18–29 years must receive a
> third mRNA vaccine. Booster mandates in young adults are expected to cause
> a net harm: per COVID-19 hospitalisation prevented, we anticipate at least
> 18.5 serious adverse events from mRNA vaccines, including 1.5–4.6
> booster-associated myopericarditis cases in males (typically requiring
> hospitalisation)…
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> As we speculated on this site a year ago, for young people the risk of the
> mRNA covid booster outweighs the benefits.  I had no idea the disparity was
> this big: 18.5 youngsters land in the hospital from the mRNA booster for
> every one which is prevented.  Sheesh, I kinda estimated the risk crossover
> point was around age 30,but now I think it must be later than that, perhaps
> 40?  Thoughts please?
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> spike
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> _______________________________________________
> extropy-chat mailing list
> extropy-chat at lists.extropy.org
> http://lists.extropy.org/mailman/listinfo.cgi/extropy-chat
>
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