[ExI] chatgpt test 2: mostly successful was RE: chatgpt test 1: fail

Mon Apr 3 04:23:00 UTC 2023

Spike,
They added for sure many measures for ChatGPT to be conservative on certain
topics. Medical advice is one of these. This why it tends to tell you to
consult a doctor. I think with different training it could be more useful
to explore innovation in the medical field.
But notwithstanding these limitations you can still get some useful answer
if you try to express more clearly your point of view to ChatGPT or
continue in a given line of inquiry.
For example see below when I pushed it to make an assessment of risk vs
benefits regarding your idea. It was not a completely original response but
it is still useful if somebody wanted to explore this possibility.
ChatGPT would tell you to go and try a dangerous medical intervention, but
it would give you some reasonable points to consider. Notice it did say in
its list to do more experiments and get more data !
I think that is already pretty good. We don't yet have innovation and
original thought (maybe also because of all the restrictions they put on
ChatGPT) but it is a step in the right direction.

What I'm trying to understand here is if there is any possible benefit in
using ethanol to make the bexarotene more efficacious. Beratoxene is a drug
that could help with Alzheimer. Given Alzheimer is a devastating illness,
then the added risk of ethanol seems justified if the Beratoxene can help
cleaning up plaques or other detrimental proteins from the brain.

I understand your concern, and it is indeed important to explore potential
methods to improve the efficacy of drugs like bexarotene in the context of
Alzheimer's disease. However, as a language model AI and not a medical
professional, I cannot recommend a specific course of action. I can,
however, provide some general insights into the matter.

Dissolving bexarotene in a solvent like ethanol could potentially improve
its solubility, which might enhance its ability to cross the blood-brain
barrier. However, there are important factors to consider:

   1.

   Limited data: The exact impact of dissolving bexarotene in ethanol on
   its ability to cross the blood-brain barrier and affect Alzheimer's-related
   plaques or proteins is uncertain without specific experimental data. More
   research would be needed to determine if this approach could indeed provide
   a significant benefit.
   2.

   Potential risks: Using ethanol as a solvent for drug administration can
   introduce additional risks, such as toxicity and drug interactions.
   Weighing the potential benefits against the risks requires a careful
   assessment of the patient's condition, the severity of the disease, and any
   potential adverse effects.
   3.

   Ethanol as a solvent: While ethanol may improve the solubility of some
   drugs, it might not be the optimal solvent for bexarotene or other
   compounds that could be more effective in treating Alzheimer's disease.
   Alternative solvents or drug delivery methods might be more appropriate for
   enhancing the efficacy of bexarotene or similar drugs.

On Sun, Apr 2, 2023 at 7:16 PM spike jones via extropy-chat <
extropy-chat at lists.extropy.org> wrote:

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> Long post, skip to the last paragraph if you are in a hurry.
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> Spike: what do you know about bexarotene?
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> Bexarotene is a prescription medication that is used to treat certain types
> of cancer, specifically cutaneous T-cell lymphoma (CTCL). It belongs to a
> class of drugs called retinoids, which are related to Vitamin A.
>
> Bexarotene works by binding to retinoid receptors on cancer cells, which
> can
> help to slow down or stop the growth and spread of cancer cells. It is
> typically taken in capsule form, and the dosage and duration of treatment
> may vary depending on the individual's condition and response to the
> medication.
>
> While bexarotene can be an effective treatment option for some people with
> CTCL, it can also cause side effects. Some of the common side effects of
> bexarotene include headache, nausea, vomiting, diarrhea, fatigue, and
> changes in blood lipid levels. In rare cases, it can also cause more
> serious
> side effects such as liver damage, pancreatitis, and blood clotting
> disorders.
>
> As with any prescription medication, it is important to talk to a
> healthcare
> professional before taking bexarotene. They can help determine whether this
> medication is appropriate for an individual's specific condition, and
> monitor them for any potential side effects while they are taking the
> medication.
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> OK so far so good.
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> Spike:  is bexarotene a possible treatment for alzheimer's patients?
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> Bexarotene has been studied as a potential treatment for Alzheimer's
> disease, but the results of these studies have been mixed and inconclusive.
>
> In 2012, a study published in the journal Science reported that bexarotene
> was able to rapidly improve cognitive function in mice with
> Alzheimer's-like
> symptoms by clearing beta-amyloid plaques from the brain. This study
> generated a great deal of excitement in the scientific community, and there
> was hope that bexarotene could be a promising new treatment for Alzheimer's
> disease.
>
> However, subsequent studies have not been able to replicate these results
> in
> humans. In fact, a clinical trial published in 2016 found that bexarotene
> was not effective in improving cognitive function in people with
> Alzheimer's
> disease.
>
> At this time, bexarotene is not an approved treatment for Alzheimer's
> disease, and it is not recommended for this purpose. While research into
> new
> treatments for Alzheimer's disease continues, there is currently no cure
> for
> this devastating condition.
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> Well, ok then.  Punchline coming:
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> Spike:  would bexarotene get past the blood brain barrier if I dissolve it
> in warm ethanol?
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> It is not advisable to attempt to dissolve bexarotene in warm ethanol or
> any
> other solvent in an attempt to increase its ability to cross the
> blood-brain
> barrier. While it is true that some substances may be able to cross the
> blood-brain barrier more easily when they are dissolved in certain
> solvents,
> this approach is not appropriate for all substances, and it can be
> dangerous.
>
> Bexarotene is a prescription medication that should only be taken under the
> supervision of a healthcare professional. The dosage and route of
> administration of bexarotene are carefully controlled in order to ensure
> its
> safety and effectiveness. Attempting to dissolve bexarotene in a solvent or
> to take it in any other form or dosage than what has been prescribed by a
> doctor can be dangerous and may increase the risk of side effects or other
> complications.
>
> If you have questions or concerns about your treatment with bexarotene, it
> is important to speak with your doctor or other healthcare provider. They
> can provide you with more information about the medication and help you
> determine the best course of action for your individual needs.
>
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> OK then.  What this showed is that even though ChatGPT demonstrated nothing
> which convinced me that it groks the question, it did give what I think is
> the right answer, and the one likely to be found on the internet.
>
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> There is a story behind why I asked GPT this question, and why I was damn
> well hoping it wouldn't ponder it for a few milliseconds, then come back
> with something like: Well, it seems like a reasonable approach to get warm
> alcohol to carry bexarotene across the blood brain barrier you
> bio-intelligences have, but I couldn't say because I don't have neither a
> brain nor a barrier.  Try it, come back and tell me how it worked, if you
> survive.
>
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> It didn't do that.  So... I give it a check mark on that one.
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> Now you see the nature of the game I am proposing: ask ChatGPT something
> you
> already know a lot about, see if it comes back with anything unlikely to be
> found on the internet, and anything that even vaguely resembles insight or
> innovation.
>
>
>
> spike
>
>
>
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