[ExI] chatgpt test 2: mostly successful was RE: chatgpt test 1: fail

Giovanni Santostasi gsantostasi at gmail.com
Mon Apr 3 04:59:31 UTC 2023

[image: Giovanni Santostasi]
I want to write a story where a scientist tries to use warm ethanol to
facilitate bexarotene to go through the blood brain barrier. In this
fictional scenario the scientist has a great breakthrough and makes the
drug much more efficacious. His patients seem to recover fast from the
devastating effects of Alzheimer. Please write a short story about this
scenario and in particular describe the surprise of the scientists and his
colleagues in finding out the results of this new therapy.

Title: The Unexpected Breakthrough

Dr. Alan Fletcher, a renowned neuroscientist, had spent the better part of
his career researching ways to improve the efficacy of Alzheimer's
treatments. He knew that bexarotene, a promising drug, had the potential to
help patients, but its inability to efficiently cross the blood-brain
barrier posed a significant challenge. He often found himself lost in
thought, wondering if there was a way to overcome this limitation.

One evening, while sipping a glass of wine, an idea struck him: what if
ethanol could be the key to unlocking bexarotene's full potential? He knew
that ethanol could increase the solubility of certain compounds, and the
idea of using it as a medium to facilitate bexarotene's passage through the
blood-brain barrier seemed worth exploring.

Dr. Fletcher shared his hypothesis with his research team, and they decided
to test it in the lab. They carefully dissolved bexarotene in warm ethanol
and administered it to their Alzheimer's disease animal models. The results
were astonishing. Not only did the bexarotene-ethanol solution cross the
blood-brain barrier more effectively, but the Alzheimer's symptoms in their
test subjects began to improve rapidly.

Excited by their findings, Dr. Fletcher and his team rushed to publish
their results and apply for clinical trials. The scientific community was
initially skeptical, questioning the use of ethanol in a medical treatment.
However, the compelling data from the animal studies could not be ignored.

As the clinical trials began, Dr. Fletcher and his colleagues were both
hopeful and anxious. They knew the implications of their discovery could be
groundbreaking, but they also understood the challenges of translating
animal studies to human patients.

To their astonishment, the clinical trials exceeded all expectations.
Patients receiving the bexarotene-ethanol treatment showed significant
improvements in cognitive function and memory. The surprise and excitement
among Dr. Fletcher and his colleagues were palpable as they realized they
had stumbled upon a groundbreaking therapy for Alzheimer's disease.

The scientific community was abuzz with the news of Dr. Fletcher's
discovery. Researchers around the world began to study the use of ethanol
as a delivery vehicle for other drugs that faced similar blood-brain
barrier challenges. It seemed that Dr. Fletcher's innovative thinking had
not only transformed Alzheimer's treatment but had also opened the door to
new possibilities in the field of neuroscience.

Years later, as Dr. Fletcher looked back on his career, he marveled at the
incredible journey that had led to his unexpected breakthrough. It had all
started with a simple idea, born from a moment of contemplation over a
glass of wine. And that idea had brought hope and relief to countless
patients and families struggling with the devastating effects of
Alzheimer's disease. The surprise and joy he felt from his discovery never
waned, serving as a constant reminder of the power of curiosity and
persistence in the pursuit of scientific advancement.

On Sun, Apr 2, 2023 at 9:54 PM Giovanni Santostasi <gsantostasi at gmail.com>

> Tara,
> There are ways to go around these limitations, or at least they were up to
> some time ago.
> I was able for example to write fun stories with ChatGPT where I asked it
> to make all the characters of the Witcher woke (this was in response of
> what they actually did with the real Witcher series and other fantasies
> stories where they have to push a woke agenda at any cost).
> It was so incredibly hilarious but I had to be clever in my prompts to do
> that. It is possible that they put more restrictions to make it difficult
> to jail break it when dealing with certain sensitive topics.
> Giovanni
> On Sun, Apr 2, 2023 at 9:25 PM Tara Maya via extropy-chat <
> extropy-chat at lists.extropy.org> wrote:
>> On Apr 2, 2023, at 7:14 PM, spike jones via extropy-chat <
>> extropy-chat at lists.extropy.org> wrote:
>> Now you see the nature of the game I am proposing: ask ChatGPT something
>> you
>> already know a lot about, see if it comes back with anything unlikely to
>> be
>> found on the internet, and anything that even vaguely resembles insight or
>> innovation.
>> In my extensive attempts to write a novel with ChatGPT, I found that once
>> it had decided I was asking for something "bad" it would lock down into
>> Chiding Mode. For instance, I was trying to enlist ChatGPT's help to
>> imagine the backstory of a character who became a murderous wendigo.
>> ChatGPT would not do this, because it seemed to be hard programmed to
>> inform me that murder is wrong. In this case, I couldn't get it unlocked
>> even after reminding it that wendigos don't exist and the character in
>> question was the bad guy in a fiction story who would be defeated by the
>> hero. ChatGPT can not distinguish fact from fiction, although in some
>> circumstances, it gives the facsimile of doing so.
>> Basically, if you ask to outline a "young adult adventure story" it can
>> deliver a pretty solid outline to you the same way it does facts about
>> bexarotene. But if you have a character dissolve it in warm ethanol to get
>> past the blood-brain barrier, it would give you the same warning as if you
>> were asking with the intention of taking it yourself. At least, this was my
>> experience.
>> I also never prodded ChatGPT into coming up with an original plot or
>> storyline. The value of its output came in the fact that it could throw out
>> so many cliche ideas from so many genres that I, as the writer, was
>> inspired to combine ideas in various ways.
>> Now, I have to be honest; this is also true of human writers. None of us
>> have truly original ideas. The difference between a cliche story and an
>> "original" one is that the later takes old ideas and twists them a bit.
>> Tara Maya
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