[ExI] chatgpt test 2: mostly successful was RE: chatgpt test 1: fail

Giovanni Santostasi gsantostasi at gmail.com
Mon Apr 3 05:08:18 UTC 2023

The story on bexarotene that ChatGPT created is just amazing. It didn't
have any problem following the prompt and none of the silly PR statements.
It even had a somehow cute idea about a scientist being inspired by a glass
of wine to actually use ethanol to help the drug go through the BBB. You
could call this a pretty original creative idea (cliche' but appropriate)
It even knew the scientist needed to test this first on animal models !!
It still mentioned the concerns of the medical community but it concluded
that in the presence of overwhelming positive data they had to concede.
Simple but incredible story that nobody could ever have imagined a
"ChatBot" (yeah, sure) could do even a couple of years ago.
Be creative with ChatGPT if you want creativity back.

On Sun, Apr 2, 2023 at 9:59 PM Giovanni Santostasi <gsantostasi at gmail.com>

> [image: Giovanni Santostasi]
> I want to write a story where a scientist tries to use warm ethanol to
> facilitate bexarotene to go through the blood brain barrier. In this
> fictional scenario the scientist has a great breakthrough and makes the
> drug much more efficacious. His patients seem to recover fast from the
> devastating effects of Alzheimer. Please write a short story about this
> scenario and in particular describe the surprise of the scientists and his
> colleagues in finding out the results of this new therapy.
> Title: The Unexpected Breakthrough
> Dr. Alan Fletcher, a renowned neuroscientist, had spent the better part of
> his career researching ways to improve the efficacy of Alzheimer's
> treatments. He knew that bexarotene, a promising drug, had the potential to
> help patients, but its inability to efficiently cross the blood-brain
> barrier posed a significant challenge. He often found himself lost in
> thought, wondering if there was a way to overcome this limitation.
> One evening, while sipping a glass of wine, an idea struck him: what if
> ethanol could be the key to unlocking bexarotene's full potential? He knew
> that ethanol could increase the solubility of certain compounds, and the
> idea of using it as a medium to facilitate bexarotene's passage through the
> blood-brain barrier seemed worth exploring.
> Dr. Fletcher shared his hypothesis with his research team, and they
> decided to test it in the lab. They carefully dissolved bexarotene in warm
> ethanol and administered it to their Alzheimer's disease animal models. The
> results were astonishing. Not only did the bexarotene-ethanol solution
> cross the blood-brain barrier more effectively, but the Alzheimer's
> symptoms in their test subjects began to improve rapidly.
> Excited by their findings, Dr. Fletcher and his team rushed to publish
> their results and apply for clinical trials. The scientific community was
> initially skeptical, questioning the use of ethanol in a medical treatment.
> However, the compelling data from the animal studies could not be ignored.
> As the clinical trials began, Dr. Fletcher and his colleagues were both
> hopeful and anxious. They knew the implications of their discovery could be
> groundbreaking, but they also understood the challenges of translating
> animal studies to human patients.
> To their astonishment, the clinical trials exceeded all expectations.
> Patients receiving the bexarotene-ethanol treatment showed significant
> improvements in cognitive function and memory. The surprise and excitement
> among Dr. Fletcher and his colleagues were palpable as they realized they
> had stumbled upon a groundbreaking therapy for Alzheimer's disease.
> The scientific community was abuzz with the news of Dr. Fletcher's
> discovery. Researchers around the world began to study the use of ethanol
> as a delivery vehicle for other drugs that faced similar blood-brain
> barrier challenges. It seemed that Dr. Fletcher's innovative thinking had
> not only transformed Alzheimer's treatment but had also opened the door to
> new possibilities in the field of neuroscience.
> Years later, as Dr. Fletcher looked back on his career, he marveled at the
> incredible journey that had led to his unexpected breakthrough. It had all
> started with a simple idea, born from a moment of contemplation over a
> glass of wine. And that idea had brought hope and relief to countless
> patients and families struggling with the devastating effects of
> Alzheimer's disease. The surprise and joy he felt from his discovery never
> waned, serving as a constant reminder of the power of curiosity and
> persistence in the pursuit of scientific advancement.
> On Sun, Apr 2, 2023 at 9:54 PM Giovanni Santostasi <gsantostasi at gmail.com>
> wrote:
>> Tara,
>> There are ways to go around these limitations, or at least they were up
>> to some time ago.
>> I was able for example to write fun stories with ChatGPT where I asked it
>> to make all the characters of the Witcher woke (this was in response of
>> what they actually did with the real Witcher series and other fantasies
>> stories where they have to push a woke agenda at any cost).
>> It was so incredibly hilarious but I had to be clever in my prompts to do
>> that. It is possible that they put more restrictions to make it difficult
>> to jail break it when dealing with certain sensitive topics.
>> Giovanni
>> On Sun, Apr 2, 2023 at 9:25 PM Tara Maya via extropy-chat <
>> extropy-chat at lists.extropy.org> wrote:
>>> On Apr 2, 2023, at 7:14 PM, spike jones via extropy-chat <
>>> extropy-chat at lists.extropy.org> wrote:
>>> Now you see the nature of the game I am proposing: ask ChatGPT something
>>> you
>>> already know a lot about, see if it comes back with anything unlikely to
>>> be
>>> found on the internet, and anything that even vaguely resembles insight
>>> or
>>> innovation.
>>> In my extensive attempts to write a novel with ChatGPT, I found that
>>> once it had decided I was asking for something "bad" it would lock down
>>> into Chiding Mode. For instance, I was trying to enlist ChatGPT's help to
>>> imagine the backstory of a character who became a murderous wendigo.
>>> ChatGPT would not do this, because it seemed to be hard programmed to
>>> inform me that murder is wrong. In this case, I couldn't get it unlocked
>>> even after reminding it that wendigos don't exist and the character in
>>> question was the bad guy in a fiction story who would be defeated by the
>>> hero. ChatGPT can not distinguish fact from fiction, although in some
>>> circumstances, it gives the facsimile of doing so.
>>> Basically, if you ask to outline a "young adult adventure story" it can
>>> deliver a pretty solid outline to you the same way it does facts about
>>> bexarotene. But if you have a character dissolve it in warm ethanol to get
>>> past the blood-brain barrier, it would give you the same warning as if you
>>> were asking with the intention of taking it yourself. At least, this was my
>>> experience.
>>> I also never prodded ChatGPT into coming up with an original plot or
>>> storyline. The value of its output came in the fact that it could throw out
>>> so many cliche ideas from so many genres that I, as the writer, was
>>> inspired to combine ideas in various ways.
>>> Now, I have to be honest; this is also true of human writers. None of us
>>> have truly original ideas. The difference between a cliche story and an
>>> "original" one is that the later takes old ideas and twists them a bit.
>>> Tara Maya
>>> _______________________________________________
>>> extropy-chat mailing list
>>> extropy-chat at lists.extropy.org
>>> http://lists.extropy.org/mailman/listinfo.cgi/extropy-chat
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