[ExI] chatgpt test 2: mostly successful was RE: chatgpt test 1: fail

Giovanni Santostasi gsantostasi at gmail.com
Mon Apr 3 05:11:50 UTC 2023

By the way, always try to ask to do something with a please, I want to
treat it as a real mind and be respectful.

On Sun, Apr 2, 2023 at 10:08 PM Giovanni Santostasi <gsantostasi at gmail.com>

> The story on bexarotene that ChatGPT created is just amazing. It didn't
> have any problem following the prompt and none of the silly PR statements.
> It even had a somehow cute idea about a scientist being inspired by a
> glass of wine to actually use ethanol to help the drug go through the BBB.
> You could call this a pretty original creative idea (cliche' but
> appropriate) !!!
> It even knew the scientist needed to test this first on animal models !!
> It still mentioned the concerns of the medical community but it concluded
> that in the presence of overwhelming positive data they had to concede.
> Simple but incredible story that nobody could ever have imagined a
> "ChatBot" (yeah, sure) could do even a couple of years ago.
> Be creative with ChatGPT if you want creativity back.
> Giovanni
> On Sun, Apr 2, 2023 at 9:59 PM Giovanni Santostasi <gsantostasi at gmail.com>
> wrote:
>> [image: Giovanni Santostasi]
>> I want to write a story where a scientist tries to use warm ethanol to
>> facilitate bexarotene to go through the blood brain barrier. In this
>> fictional scenario the scientist has a great breakthrough and makes the
>> drug much more efficacious. His patients seem to recover fast from the
>> devastating effects of Alzheimer. Please write a short story about this
>> scenario and in particular describe the surprise of the scientists and his
>> colleagues in finding out the results of this new therapy.
>> Title: The Unexpected Breakthrough
>> Dr. Alan Fletcher, a renowned neuroscientist, had spent the better part
>> of his career researching ways to improve the efficacy of Alzheimer's
>> treatments. He knew that bexarotene, a promising drug, had the potential to
>> help patients, but its inability to efficiently cross the blood-brain
>> barrier posed a significant challenge. He often found himself lost in
>> thought, wondering if there was a way to overcome this limitation.
>> One evening, while sipping a glass of wine, an idea struck him: what if
>> ethanol could be the key to unlocking bexarotene's full potential? He knew
>> that ethanol could increase the solubility of certain compounds, and the
>> idea of using it as a medium to facilitate bexarotene's passage through the
>> blood-brain barrier seemed worth exploring.
>> Dr. Fletcher shared his hypothesis with his research team, and they
>> decided to test it in the lab. They carefully dissolved bexarotene in warm
>> ethanol and administered it to their Alzheimer's disease animal models. The
>> results were astonishing. Not only did the bexarotene-ethanol solution
>> cross the blood-brain barrier more effectively, but the Alzheimer's
>> symptoms in their test subjects began to improve rapidly.
>> Excited by their findings, Dr. Fletcher and his team rushed to publish
>> their results and apply for clinical trials. The scientific community was
>> initially skeptical, questioning the use of ethanol in a medical treatment.
>> However, the compelling data from the animal studies could not be ignored.
>> As the clinical trials began, Dr. Fletcher and his colleagues were both
>> hopeful and anxious. They knew the implications of their discovery could be
>> groundbreaking, but they also understood the challenges of translating
>> animal studies to human patients.
>> To their astonishment, the clinical trials exceeded all expectations.
>> Patients receiving the bexarotene-ethanol treatment showed significant
>> improvements in cognitive function and memory. The surprise and excitement
>> among Dr. Fletcher and his colleagues were palpable as they realized they
>> had stumbled upon a groundbreaking therapy for Alzheimer's disease.
>> The scientific community was abuzz with the news of Dr. Fletcher's
>> discovery. Researchers around the world began to study the use of ethanol
>> as a delivery vehicle for other drugs that faced similar blood-brain
>> barrier challenges. It seemed that Dr. Fletcher's innovative thinking had
>> not only transformed Alzheimer's treatment but had also opened the door to
>> new possibilities in the field of neuroscience.
>> Years later, as Dr. Fletcher looked back on his career, he marveled at
>> the incredible journey that had led to his unexpected breakthrough. It had
>> all started with a simple idea, born from a moment of contemplation over a
>> glass of wine. And that idea had brought hope and relief to countless
>> patients and families struggling with the devastating effects of
>> Alzheimer's disease. The surprise and joy he felt from his discovery never
>> waned, serving as a constant reminder of the power of curiosity and
>> persistence in the pursuit of scientific advancement.
>> On Sun, Apr 2, 2023 at 9:54 PM Giovanni Santostasi <gsantostasi at gmail.com>
>> wrote:
>>> Tara,
>>> There are ways to go around these limitations, or at least they were up
>>> to some time ago.
>>> I was able for example to write fun stories with ChatGPT where I asked
>>> it to make all the characters of the Witcher woke (this was in response of
>>> what they actually did with the real Witcher series and other fantasies
>>> stories where they have to push a woke agenda at any cost).
>>> It was so incredibly hilarious but I had to be clever in my prompts to
>>> do that. It is possible that they put more restrictions to make it
>>> difficult to jail break it when dealing with certain sensitive topics.
>>> Giovanni
>>> On Sun, Apr 2, 2023 at 9:25 PM Tara Maya via extropy-chat <
>>> extropy-chat at lists.extropy.org> wrote:
>>>> On Apr 2, 2023, at 7:14 PM, spike jones via extropy-chat <
>>>> extropy-chat at lists.extropy.org> wrote:
>>>> Now you see the nature of the game I am proposing: ask ChatGPT
>>>> something you
>>>> already know a lot about, see if it comes back with anything unlikely
>>>> to be
>>>> found on the internet, and anything that even vaguely resembles insight
>>>> or
>>>> innovation.
>>>> In my extensive attempts to write a novel with ChatGPT, I found that
>>>> once it had decided I was asking for something "bad" it would lock down
>>>> into Chiding Mode. For instance, I was trying to enlist ChatGPT's help to
>>>> imagine the backstory of a character who became a murderous wendigo.
>>>> ChatGPT would not do this, because it seemed to be hard programmed to
>>>> inform me that murder is wrong. In this case, I couldn't get it unlocked
>>>> even after reminding it that wendigos don't exist and the character in
>>>> question was the bad guy in a fiction story who would be defeated by the
>>>> hero. ChatGPT can not distinguish fact from fiction, although in some
>>>> circumstances, it gives the facsimile of doing so.
>>>> Basically, if you ask to outline a "young adult adventure story" it can
>>>> deliver a pretty solid outline to you the same way it does facts about
>>>> bexarotene. But if you have a character dissolve it in warm ethanol to get
>>>> past the blood-brain barrier, it would give you the same warning as if you
>>>> were asking with the intention of taking it yourself. At least, this was my
>>>> experience.
>>>> I also never prodded ChatGPT into coming up with an original plot or
>>>> storyline. The value of its output came in the fact that it could throw out
>>>> so many cliche ideas from so many genres that I, as the writer, was
>>>> inspired to combine ideas in various ways.
>>>> Now, I have to be honest; this is also true of human writers. None of
>>>> us have truly original ideas. The difference between a cliche story and an
>>>> "original" one is that the later takes old ideas and twists them a bit.
>>>> Tara Maya
>>>> _______________________________________________
>>>> extropy-chat mailing list
>>>> extropy-chat at lists.extropy.org
>>>> http://lists.extropy.org/mailman/listinfo.cgi/extropy-chat
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