[Paleopsych] New Scientist: Civilisation has left its mark on our genes
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Civilisation has left its mark on our genes
http://www.newscientist.com/article.ns?id=dn8483&print=true
* 22:00 19 December 2005
* Bob Holmes
Darwins fingerprints can be found all over the human genome. A detailed look
at
human DNA has shown that a significant percentage of our genes have been
shaped
by natural selection in the past 50,000 years, probably in response to
aspects of
modern human culture such as the emergence of agriculture and the shift
towards
living in densely populated settlements.
One way to look for genes that have recently been changed by natural
selection is
to study mutations called single-nucleotide polymorphisms (SNPs)
single-letter
differences in the genetic code. The trick is to look for pairs of SNPs that
occur together more often than would be expected from the chance genetic
reshuffling that inevitably happens down the generations.
Such correlations are known as linkage disequilibrium, and can occur when
natural
selection favours a particular variant of a gene, causing the SNPs nearby to
be
selected as well.
Robert Moyzis and his colleagues at the University of California, Irvine,
US,
searched for instances of linkage disequilibrium in a collection of 1.6
million
SNPs scattered across all the human chromosomes. They then looked carefully
at
the instances they found to distinguish the consequences of natural
selection
from other phenomena, such as random inversions of chunks of DNA, which can
disrupt normal genetic reshuffling.
This analysis suggested that around 1800 genes, or roughly 7% of the total
in the
human genome, have changed under the influence of natural selection within
the
past 50,000 years. A second analysis using a second SNP database gave
similar
results. That is roughly the same proportion of genes that were altered in
maize
when humans domesticated it from its wild ancestors.
Domesticated humans
Moyzis speculates that we may have similarly domesticated ourselves with the
emergence of modern civilisation.
One of the major things that has happened in the last 50,000 years is the
development of culture, he says. By so radically and rapidly changing our
environment through our culture, weve put new kinds of selection [pressures]
on
ourselves.
Genes that aid protein metabolism perhaps related to a change in diet with
the
dawn of agriculture turn up unusually often in Moyziss list of recently
selected
genes. So do genes involved in resisting infections, which would be
important in
a species settling into more densely populated villages where diseases would
spread more easily. Other selected genes include those involved in brain
function, which could be important in the development of culture.
But the details of any such sweeping survey of the genome should be treated
with
caution, geneticists warn. Now that Moyzis has made a start on studying how
the
influence of modern human culture is written in our genes, other teams can
see if
similar results are produced by other analytical techniques, such as
comparing
human and chimp genomes.
Journal reference: Proceedings of the National Academy of Sciences (DOI:
10.1073/pnas.0509691102)
Evolution Learn more about the struggle to survive in our comprehensive
[11]special report.
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Weblinks
* [18]Robert Moyzis, University of California
* [19]http://www.ucihs.uci.edu/biochem/faculty/moyzis.html
* [20]SNP fact sheet, Human Genome Project
* [21]http://www.ornl.gov/sci/techresources/Human_Genome/faq/snps.shtml
* [22]Evolution special report, New Scientist
* [23]http://www.newscientist.com/channel/life/evolution
References
11. http://www.newscientist.com/channel/life/evolution
12. http://www.newscientist.com/article.ns?id=dn8254
13. http://www.newscientist.com/article.ns?id=dn8254
14. http://www.newscientist.com/article.ns?id=mg18725174.600
15. http://www.newscientist.com/article.ns?id=mg18725174.600
16. http://www.newscientist.com/article.ns?id=mg18725071.100
17. http://www.newscientist.com/article.ns?id=mg18725071.100
18. http://www.ucihs.uci.edu/biochem/faculty/moyzis.html
19. http://www.ucihs.uci.edu/biochem/faculty/moyzis.html
20. http://www.ornl.gov/sci/techresources/Human_Genome/faq/snps.shtml
21. http://www.ornl.gov/sci/techresources/Human_Genome/faq/snps.shtml
22. http://www.newscientist.com/channel/life/evolution
23. http://www.newscientist.com/channel/life/evolution
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