[ExI] forwarding for damien, access to neuroscience paper

[spike]

He was getting a send error.  Anyone else getting that?

Does anyone have e-access to the neuroscience paper

Dragoi, G. & Tonegawa, S. Nature 469, 397-401(2011)

which is discussed in the same issue by Moser & Moser? I'd like to see the
original paper. The Mosers comment:

<They initially recorded sequences of firing in place cells when mice that
had been running on one arm of an L-shaped track were resting at food
locations near the ends of that arm. As expected, place-cell firing
sequences were replayed during pauses at the food locations. The authors
then opened the other rack's arm to allow the animals to run across the
entire L. Surprisingly, they found that when the mice were resting before
gaining access to the second arm, some of the firing sequences in their
brain matched those subsequently recorded on the new arm. They refer to this
predictive activity as preplay (Fig. 1).

One might argue that, on exposure of the animal to the extended segments,
preplay merely reflects replay of activity associated with the familiar
first part of the maze, the shape of which was similar to that of the new
part. But mice with no prior experience on any track also showed preplay.
Together, these observations suggest that, in a new environment, activity
sequences involving a specific assembly of cells are selected from already
existing sequences in the network...

Dragoi and Tonegawa show that as many as 15% of the spiking events that
occurred during resting correlated significantly with subsequent sequences
in the new environment. This relatively large number of
predictive- spiking events is worthy of some reflection. If preconfigured
sequences were used as a raw material to encode sequences in new
environments, and each environment received a unique set of firing
sequences, then the hippocampus might soon run out of templates. >

Damien Broderick