[ExI] Limits of human modification

[Rafal Smigrodzki]

I think that the most appropriate test for permissibility of human germline
modifications should be a composite of predicted net impact on social
utility assessed by a subjective measure and an objective measure.

The objective measure would be a suitable econometric instrument, such as
per capita GDP. Any modification that increases GDP in the long term or is
GDP-neutral should be allowed, unless it fails the subjective part of the
test. Of course, the same modification could differentially impact GDP in
various situations, so the permissibility of a modification would be
subject to review. A first-generation IQ boost could become a net drag on
the economy where third-generation boost is needed for an entry job, so it
might become unacceptable. Sponsors of a modification could pre-pay for a
GDP-negative modification, for example contributing to a fund which would
reimburse for losses attributable to the modification.

The subjective measure would be a test of well-being. Modifications that
reduce predicted well-being below baseline of the unmodified genotype
should be disallowed.

Note that unmodified viable genomes produced by natural methods would be
grandfathered in. This ethical approach would not try to generate a
baseline quality threshold for allowable genomes but rather it accepts
existing genomes and imposes a direction of change measured in economic and
experiential terms, aiming for improving economic efficiency and well-being
in each generation.

Rafał
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