[extropy-chat] Aging as a function of bone marrow degradation

[Lifespan Pharma Inc/ MFJ-CTO]

Actually I have been thinking about this for many years (over 2  
decades)  and what  has to be done is to put the body into
near hibernation state and slow metabolism to a crawl.  The introduced 
cells have to be able to function at a high
rate even under these conditions and perhaps even have a metabolism that 
either stops or self-destructs at
normal body temperatures and metabolism as a failsafe.  The body 
metabolism over perhaps a month might be equivalent to an hour while the 
introduced cells are working at breakneck speed and may be able do a 
years work over that month.

These cells would have to metabolize energy sources that the body would 
otherwise consider inert.
The introduced cells should have to be able to carry away, or 
metabolize  dangerous  waste biological products of the
hibernating body as well.
Just think about the creation of several  separate secondary 
"programmable" armies of specialized minicells.
We use the term nanobot without the slightest clue as to what they might 
be or how they would operate so this is quite in line with that concept.
What we might have to do is provide them with an environment where they 
can work efficiently
and with undue interference from normal body processes.

Indeed it might take interaction with a number of supervisory systems 
ranging from MRI type scanners , and AI complexity
oversight to move this process from start to finish without killing the 
customer.

A new stem cell population would need to be grown beforehand, perhaps in 
a controlled way sequestered in the body
much like an encapsulated tumor or embryo and harvested prior to the 
regerarative procedure.
And the leuekemia analogy is a good one, perhaps we shall find  
deliberate creation of a cancerous stem cell
population the best way to create a large population of embyonic case 
type cells to infuse back. Remember, cancer cells
can slither around and take root in all manner of places in the body 
quite efficiently.  The trick is to be able to turn on and off this
mechanism on demand. 

I think  that  with the convergence of technologies at a singularity 
level with AI level computational capacity there is hope to
create this level of sophistication in the mangement of biological systems.

I did not say that this would be easy. 

Just remember that what we consider normal in terms of computer chips 
and their functions would have been
considered magic or witchcraft  and idle fantasy as little as 100 years ago.

Morris.




Brett Paatsch wrote:

>     From: Lifespan Pharma Inc/ MFJ-CTO <mailto:megao at sasktel.net>
>     To: ExI chat list <mailto:extropy-chat at lists.extropy.org>
>     Sent: Thursday, November 10, 2005 6:50 PM
>     Subject: [extropy-chat] Aging as a function of bone marrow degradation
>
>     But that's the challenge, to switch every body cell on as a
>     totipotent cancer cell similtaneously, slow down the metabolism so
>     none divides,   circulate a swarm of autoimmune cells to tag
>     defective cells for future destruction, reset all the switches
>     , crank up the metabolism and send in the scavenger cells to wack
>     out the burned out cells and infuse a new batch of stem cells
>     into every tissue to rebuild tissues.  A massive order, but like
>     with  "Doctor Who" it is steady state-evolution which will replace
>     natural selection by death or illness.  The trick is to maintain 
>     the memory and consciousness of the brain through this
>     housecleaning operation.
>
> "Every body cell" would give you a base set of around 100 trillion cells.
>  
> Lets say you wanted to switch every body cell to a cancer cell (I 
> don't think
> that even makes sense - but lets say), how would you do it?  With what
> hormone or molecule?  Or are you thinking nanobots?
>  
> How would you slow down metabolism so no cells divide? Metabolism
> works in such a way that when cells stop getting fed (glucose levels in
> blood are low) some cells (in the liver say) go into glucose or ketone
> bodies from fat production specifically to fed other cells (like brain 
> cells)
> so that they wont die when there is no dietary glucose available.
> Or by slowing down metabolism did you mean cryonics? 
>  
> Where do your autoimmune cells that are to do the tagging to come
> from themselves (you stopped cell division -somehow- remember)? What
> cell markers are they to zero in on?  If you've made *every* cell 
> cancerous
> how many macrophage/eater cells are you going to have to have ? How do
> you imagine they'll fit geometrically in the body made of other cells?
>  
> Are your scavenger cells "carrying" the new batch of stem cells? How
> are they getting through the blood brain barrier?
>  
> I am not even slightly an expert in this area but I think I know enough
> to recognize that what you have said above doesn't make any biological
> sense. 
>  
> I mean no offense but it seems like you might be repeating something
> that you have heard someone else say which didn't make sense but
> which you didn't understand well enough to realise that it didn't make
> sense.
>  
> Brett Paatsch


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