[ExI] it's your choice

[William Flynn Wallace]

You must know things I don't about 23 and me.  How do you know the surveys
are failures?   bill w

On Sat, Apr 4, 2020 at 11:44 AM spike jones via extropy-chat <
extropy-chat at lists.extropy.org> wrote:

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> *From:* extropy-chat <extropy-chat-bounces at lists.extropy.org> *On Behalf
> Of *William Flynn Wallace via extropy-chat
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> >…I just have no feelings for 3 cousins - there must be hundreds or
> thousands of them…
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> Ja.
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> >…   I don't know what you get out of it, Spike, but I hope you get all
> you want…
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> bill w
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> I want to see if we can succeed where 23&Me failed.
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> The idea behind 23 was get a bunch of people to do DNA tests, group them,
> have them fill out surveys about their health, see if there are certain
> conditions that run in certain DNA-clades.
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> Good idea, but I would call it generally a failure for a reason we mighta
> anticipated: surveys by users on their own health is some of the lowest
> quality data there is.  Reason: plenty of people, really most people, don’t
> really know what is wrong with them and don’t know what is right with them.
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> For instance… plenty of people imagine they have conditions they do not
> have.  Or they imagine they have conditions that they keep under control by
> drinking four drops of {grapefruit seed extract, vitamin x, supply
> condition and treatment} but they don’t have that condition, never did.
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> Populations don’t know what is right with them either, because they aren’t
> aware of that condition at all, they never heard of it.  They miss some
> signals, such as a group relative immunity to something that rips a
> different DNA group elsewhere.  For instance: suppose an Eastern European
> DNA group doesn’t ever get acne during adolescence.  We already know some
> teens never get that, but it would be easy to miss if they is a genetic
> component in there somewhere.  They can ask about it on the survey and
> still miss it, but I realized long after the fact that I went thru those
> years and never did have more than a very slight case of that, while others
> were torn up with it.  Something like that would be easy to miss.
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> Well, OK then, the 23 experiment may have been a general failure, but the
> idea was good.
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> Now suppose we can put together some kind of database which allows
> software to scour through and look for signals.  And suppose that over
> time, accurate DNA genealogical information does accumulate, along with
> reliable information on the location of the roots back when people
> travelled less than the do now and hundreds of generations went by with not
> a lot of DNA coming in or going out.  We find better ways to map out all
> that, then we try the 23&Me experiment again, but this time with more and
> better medical diagnostics, more and better DNA-genealogy and so forth.
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> BillW, regarding all I want: I am setting up a database to collect groups
> of descendants of a common ancestor.  Then we can look for medical
> conditions within those groups, searching for stuff that might be out of
> the normal range.
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> When you think about it, evolutionary psychology is kinda sorta that same
> idea, only that looks at behaviors, rather than medical conditions or
> physical traits.  I will leave that to the experts, while I do my thing:
> looking for stuff like a particular oddball medical condition that seems
> more prevalent in a group for instance.
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> spike
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