[ExI] High resolution MRI

[Neil Halelamien]

Also, some of the things which distinguish this from a typical clinical MRI
and various other notes:

* unlike a lot of other mouse brain MRI research, the brains were left
inside the cranium, preventing structural distortion/damage
* the brains were fixed and treated with an MRI contrast agent
* they used a 9.4T magnet (in contrast, typical clinical MRI is maybe 1-3T)
* if I understand correctly, algorithms were then used to automatically
segment the different brain areas (33 total) apart from each other, and the
area data from the 6 brains was combined to form the atlas
* in general, the research is kind of neat, combining a number of
already-existing techniques to create a useful atlas

On 7/11/07, Neil Halelamien <neilh at caltech.edu> wrote:
>
> The NeuroImage article is here, although I think it requires an
> institutional subscription:
>
> http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WNP-4NX8MST-7&_user=1010281&_coverDate=06%2F07%2F2007&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000050264&_version=1&_urlVersion=0&_userid=1010281&md5=0d9d038b1101b4c523e05e0c7cdcd4e3
>
>
> Here's the abstract:
> Magnetic resonance microscopy (MRM), when used in conjunction with active
> staining, can
> produce high-resolution, high-contrast images of the mouse brain. Using
> MRM, we imaged in
> situ the fixed, actively stained brains of C57BL/6J mice in order to
> characterize the
> neuroanatomical phenotype and produce a digital atlas. The brains were
> scanned within the
> cranium vault to preserve the brain morphology, avoid shape distortions,
> and to allow an
> unbiased shape analysis. The high-resolution imaging used a T1-weighted
> scan at 21.5 mm
> isotropic resolution, and an eight-echo multiecho scan, post-processed to
> obtain an enhanced T2
> image at 43 mm resolution. The two image sets were used to segment the
> brain into 33
> anatomical structures. Volume, area, and shape characteristics were
> extracted for all segmented
> brain structures. We also analyzed the variability of volumes, areas and
> shape characteristics.
> The coefficient of variation of volume had an average value of 7.0.
> Average anatomical images
> of the brain for both the T1 weighted and T2 images were generated,
> together with an average
> shape atlas, and a probabilistic atlas for 33 major structures. These
> atlases, with their associated
> metadata, will serve as baseline for identifying neuroanatomical
> phenotypes of additional strains,
> and mouse models now under study. Our efforts were directed toward
> creating a baseline for
> comparison with other mouse strains and models of neurodegenerative
> diseases.
>
> On 7/10/07, John K Clark <jonkc at att.net> wrote:
> >
> > Some scientists at Duke University have made a MRI image of a mouse
> > brain with "100,000 times higher resolution than a clinical MRI scan".
> > 100,000!
> >
> > http://www.sciencedaily.com/releases/2007/07/070709145329.htm
> >
> >   John K Clark
> >
> >
> >
> >
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> >
>
>
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