[ExI] Autophagy and Aging

[mark M]

Very interesting!
 
 

 
Are there any negative side effects Stuart  
 
 

 
 

 
 
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> On May 3, 2019 at 6:57 PM,  <Stuart LaForge (mailto:avant at sollegro.com)>  wrote:
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> For those of you who might have missed it, the 2016 Nobel Prize in 
> Medicine or Physiology went to Yoshinori Ohsumi for his work 
> elucidating the mechanisms of autophagy. Briefly, autophagy is when 
> cells are induced to digest their own damaged proteins to salvage 
> amino acids for other purposes. It is evolutionarily a highly 
> conserved process that we share with creatures as primitive as yeast. 
>
> Here is a very good open access article in Cell about the process of 
> autophagy and its role in health and disease: 
>
> https://www.cell.com/cell/fulltext/S0092-8674(11)01276-1?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867411012761%3Fshowall%3Dtrue 
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> What I have learned is that when you don't eat for at least 16 hours 
> or so, your body starts the process of autophagy where it digests worn 
> out and damaged proteins in order to use the amino acids to synthesize 
> new fully-functional proteins as well as synthesize glucose for your 
> brain and your liver through the process of gluconeogenesis. Autophagy 
> peaks between 24 and 48 hours and then declines to a slow and steady 
> rate, once your body switches to burning your fat stores to obtain 
> ketones to fuel your brain instead of glucose from amino acids. 
>
> The upshot of this is that short fasts of between 24 and 48 hours do 
> wonders for your health potentially reversing some of the effects of 
> aging caused by the build up of worn out proteins and organelles in 
> cells. I have been experimenting on myself by eating every other day 
> both to both lose weight and to induce autophagy and I can't help but 
> notice beneficial effects. My mood is improved, I feel sharper and 
> more energetic with a general sense of well-being. Moreover, I have 
> lost about 15 pounds in three weeks this way. 
>
> On my fasting days, I try to get by on black morning coffee and a 
> multivitamin and then water alone for the rest of the day. But if I 
> get too hungry, then I eat a tablespoon of pure fat like butter, olive 
> oil, or coconut oil. But I avoid eating any carbs or protein for the 
> whole time. 
>
> On my eating days, I pretty much eat anything I feel like eating, 
> including dessert. 
>
> For those of you who don't need to lose weight, I would just eat as 
> much pure fat as you can stomach but nothing else, on one or two days 
> a week so you can induce autophagy without losing any weight. Then 
> make it a point to eat extra protein after the one or two fat only 
> days are finished so you don't lose muscle mass. 
>
> Anyways, water only fasting every other day is working for me so I 
> thought I would share. 
>
> Stuart LaForge 
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